Manufacturer |
Boster
|
Category |
|
Type |
Proteins Recombinant |
Specific against |
other |
Format |
Solution |
Amount |
10ug |
Item no. |
BOS-PROTP56962 |
eClass 6.1 |
34160400 |
eClass 9.0 |
42020190 |
Available |
|
Contents |
The STX17 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 0.15M NaCl, 1mM DTT and 30% glycerol. |
Description |
STX17 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 252 amino acids (1-229) and having a molecular mass of 28.6kDa. STX17 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. |
Gene name |
STX17 |
Protein function |
SNAREs, soluble N-ethylmaleimide-sensitive factor- attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. STX17 is a SNARE of the autophagosome involved in autophagy through the direct control of autophagosome membrane fusion with the lysosome membrane (PubMed:23217709, PubMed:25686604). May also play a role in the early secretory pathway where it may maintain the architecture of the endoplasmic reticulum-Golgi intermediate compartment/ERGIC and Golgi and/or regulate transport between the endoplasmic reticulum, the ERGIC and the Golgi (PubMed:21545355). |
Purification |
Greater than 85.0% as determined by SDS-PAGE. |
Shipping |
Shipped with wet ice |
Short description |
STX17 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 252 amino acids (1-229) and having a molecular mass of 28.6kDa. STX17 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. |
Storage |
Store in -20° C for long term storage. After reconstitution, store in 4° C for short term usage within a few days. Avoid freeze-thaw cycles. |
Subcellular localization |
Endoplasmic reticulum membrane |
Format Information |
Sterile Filtered clear solution. |
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