BT-13

924537-98-4

C23H27F4N3O4S

DMSO : 25 mg/mL (48.31 mM; Need ultrasonic)

Protein Tyrosine Kinase/RTK

BT-13 is a potent and selective glial cell line-derived neurotrophic factor (GDNF) receptor RET agonist independently of GFLs, promoting neurite growth from sensory neurons in vitro and attenuates experimental neuropathy in the Rat^[1]. IC50 & Target: GDNF receptor RET^[1]. In Vitro: BT-13 stimulates phosphorylation of RET, as well as RET-dependent intracellular signaling, but activated neither NGF receptor TrkA nor BDNF receptor TrkB nor intracellular signaling in the absence of RET^[1]. In Vivo: BT-13 (20 and 25mg/kg in rats induced by ligation of left L5 and L6 spinal nerves) has a slight antinociceptive/antihyperalgesic effect and protected DRG neurons in rats with surgery-induced neuropathy^[1].