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GNE-9605

GNE-9605

Item no.	CS-3297-10mg
Manufacturer	ChemScene
Amount	10mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Similar products	1536200-31-3
Available
CAS	1536200-31-3
Purity	>98%
Formula	C17H20ClF4N7O
MWt	449.83
Solubility	DMSO : >= 60 mg/mL (133.38 mM)
Clinical Information	No Development Reported
Pathway	Autophagy
Target	LRRK2
Biological Activity	GNE-9605 is a highly potent, selective, and brain-penetrant LRRK2 inhibitor with IC50 of 19 nM. IC50 value: Target: LRRK2 GNE-9605 retained excellent predicted human metabolic stability when assayed in human liver microsomes and hepatocytes. In addition, no reversible or time-dependent inhibition of any of the major CYP isoforms was observed. The demonstrated metabolic stability, brain penetration across multiple species, and selectivity of these inhibitors support their use in preclinical efficacy and safety studies.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 10mg

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Delivery expected until 9/4/2025

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