Paeonol

552-41-0

C9H10O3

DMSO : >= 38 mg/mL (228.68 mM)

Autophagy; Neuronal Signaling

Paeonol is an active extraction from the root of Paeonia suffruticosa, Paeonol inhibits MAO-A and MAO-B with IC₅₀ of 54.6 uM and 42.5 uM, respectively. IC50 & Target: IC50: 42.5 uM (MAO-B), 54.6 uM (MAO-A)^[1] In Vitro: Paeonol is found to be inhibitory against MAO A in a dose-dependent manner with IC₅₀ value of 54.6 uM. Paeonol is shown to inhibit MAO-B in a dose-dependent manner with the IC₅₀ of 42.5 uM. For Paeonol, the K_i is estimated to be 51.1 uM. The inhibition of Paeonol on MAO B is of competitive type with K_i value of 38.2 uM^[1]. In Vivo: The 200 mg/kg Paeonol+I/R group [AN/V (%): 7.6+/-2.2, p<0.01] and 100 mg/kg Paeonol+I/R group [AN/V (%): 9.4+/-2.8, p<0.05] both show lesser extents of no-reflow area in the ventricles compared with the I/R group [AN/V (%): 18.2+/-2.9]. In particular, the 200 mg/kg Paeonol + I/R group experienced markedly alleviated no-reflow in the whole heart [AN/WH (%): 4.6+/-1, p<0.05] compared with the I/R group [AN/WH (%): 10.0+/-1.9]^[2].