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Salubrinal

Salubrinal

Item no.	V0058-25mg
Manufacturer	InvivoChem LLC
CASRN	405060-95-9
Amount	25 mg
Quantity options	100 mg 10 mg 1 g 250 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0058CAS #:405060-95-9Purity >=98% Description: Salubrinal is a novel, potent, cell-permeable and selective inhibitor of eIF2alpha (eukaryotic translation initiation factor 2 subunit alpha) dephosphorylation with potential anticancer activity. It inhibits ER stress-mediated apoptosis with EC50 of ca.15 uM in cell-free assays. The eukaryotic translation initiation factor 2 subunit alpha (eIF2alpha) is crucial in protein synthesis. eIF2alpha phosphorylation played an important role in protecting cells from apoptosis. Salubrinal selectively suppresses the phosphatase complexes that dephosphorylate eIF-2alpha. Salubrinal inhibits eIF2alpha dephosphorylation by inhibiting the PP1/GADD34 complex. Salubrinal inhibits HSV replication with IC50 of ca. 3uM by inhibiting eIF2alpha dephosphorylation. Description: References: Science, 2005, 307(5711), 935-939.; Am J Physiol Regul Integr Comp Physiol, 2009, 296(1), 178-184. References:
Molecular Weight (MW)	479.81
Formula	C21H17Cl3N4OS
CAS No.	405060-95-9
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 96 mg/mL (200.07 mM)
	Water: < 1 mg/mL (slightly soluble or insoluble)
	Ethanol: 2 mg/mL (4.16 mM)
Other info	InChi Key: LCOIAYJMPKXARU-VAWYXSNFSA-N InChi Code: InChI=1S/C21H17Cl3N4OS/c22-21(23, 24)19(27-17(29)12-11-14-6-2-1-3-7-14)28-20(30)26-16-10-4-8-15-9-5-13-25-18(15)16/h1-13, 19H, (H, 27, 29)(H2, 26, 28, 30)/b12-11+ SMILES Code: O=C(NC(NC(NC1=C2N=CC=CC2=CC=C1)=S)C(Cl)(Cl)Cl)/C=C/C3=CC=CC=C3
Chemical Name	(E)-3-phenyl-N-[2, 2, 2-trichloro-1-(quinolin-8-ylcarbamothioylamino)ethyl]prop-2-enamide

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Amount: 25 mg

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Delivery expected until 11/6/2025

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