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Arimoclomol (maleate)

Arimoclomol (maleate)

Item no.	CS-0062887-10mg
Manufacturer	ChemScene
Amount	10mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	289893-26-1
Similar products	289893-26-1
Available
Alternative Names	BRX-220
CAS	289893-26-1
Purity	>98%
MWt	429.85
Formula	C18H24ClN3O7
Solubility	DMSO : 250 mg/mL (581.60 mM; Need ultrasonic); H2O : 100 mg/mL (232.64 mM; Need ultrasonic)
Clinical Information	Phase 3
Pathway	Metabolic Enzyme/Protease; Cell Cycle/DNA Damage
Target	HSP; HSP
Biological Activity	Arimoclomol maleate (BRX-220) is a co-inducer of heat shock proteins (HSP)^[1]. Arimoclomol protects motor neurons by enhancing Hsp expression, thus directly affecting protein aggregation and clearance of misfolded assemblies via the proteasome-ubiquitin system^[2]. IC50 & Target: HSP^[1] In Vivo: Arimoclomol (BRX-220; 20 mg/kg; orally administered for 5 d) has a protective effect against cholecystokinin-octapeptide (CCK)-induced acute pancreatitis^[1].
Research Area	Metabolic Disease; Inflammation/Immunology; Neurological Disease

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Amount: 10mg

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Delivery expected until 11/6/2025

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