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Phospho-IKKb(Y199) Antibody

Phospho-IKKb(Y199) Antibody

Item no.	ABC-AP3127a-ev
Manufacturer	Abcepta
Amount	80 ul
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Applications	WB
Specific against	other
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	IKBKB, IKKB, Inhibitor of nuclear factor kappa-B kinase subunit beta, I-kappa-B kinase 2, Nuclear factor NF-kappa-B inhibitor kinase beta, IKK-beta, IKK2, NFKBIKB, IkBKB, I-kappa-B-kinase beta, IKK-B
Available
Primary Accession	O14920
Antigen Type	Synthetic Peptide
Application	WB
Bio Background	NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the inhibitory I-kappa-B proteins by kinases (IKKa or IKKb) leads to the dissociation of the inhibitor/NF-kappa-B complex and marks the inhibitors for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs.
Bio References	Tomasoni, S., et al., Transplantation 79(9):1056-1061 (2005). Lappas, M., et al., Endocrinology 146(3):1491-1497 (2005). Carcamo, J.M., et al., Mol. Cell. Biol. 24(15):6645-6652 (2004). May, M.J., et al., J. Biol. Chem. 279(44):45528-45539 (2004). Ea, C.K., et al., Proc. Natl. Acad. Sci. U.S.A. 101(43):15318-15323 (2004).
Clonality	Polyclonal
Clone/Animal Names	RB6996
Gene ID	3551
Gene Name	IKBKB
Subtitle	Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	The anti-Phospho-IKKb-Y199 Pab (Cat. #AP3127a) is used in Western blot to detect Phospho-IKKb-Y199 in Y79 tissue lysate
Type image 1	WB
Dilution image 1	1:1000
Other Accession	Q9QY78; O88351; Q95KV0
Predicted	B, M, Rat
Isotype	Rabbit Ig
Calculated MW	86564
Antigen Source	HUMAN
Target/Specificity	This IKKb Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y199 of human IKKb.
NCBI Accession	NP_001177649.1; NP_001229707.1; NP_001547.1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 80 ul

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Delivery expected until 9/4/2025

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