LGR5 Antibody

O75473

Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development.

8549

Purified Rabbit Polyclonal Antibody

Western blot analysis in M.skeletal muscle lysate, R.skeletal muscle lysate, Hela cell lysates, HepG2 cell lysate and SH-SYY cell lysates.

Overlay histogram showing SH-SY5Y cells stained with anti-LGR5 antibody(green). Isotype control antibody(blue) was rabbit IgG used under the same conditions. Acquisition of >10000 events was performed.