Comparison

Rufinamide

Item no. CS-1455-100mg
Manufacturer ChemScene
Amount 100mg
Category
Type Molecules
Specific against other
ECLASS 10.1 32169090
ECLASS 11.0 32169090
UNSPSC 12000000
Similar products 106308-44-5
Available
Alternative Names
CGP 33101; E 2080; RUF 331
CAS
106308-44-5
Purity
>98%
Formula
C10H8F2N4O
MWt
238.19
Solubility
H2O : < 0.1 mg/mL (insoluble); DMSO : 50 mg/mL (209.92 mM; Need ultrasonic)
Clinical Information
Launched
Pathway
Others
Target
Others
Biological Activity
Rufinamide(E 2080; CGP 33101; RUF 331) is a new antiepileptic agent that differs structurally from other antiepileptic drugs and is approved as adjunctive therapy for Lennox-Gastaut syndrome (LGS). IC50 Value: Target: in vitro: in vivo: Rufinamide and amitriptyline alleviated injury-induced mechanical allodynia for 4 h (maximal effect: 0.10 +/- 0.03 g (mean +/- SD) to 1.99 +/- 0.26 g for rufinamide and 0.25 +/- 0.22 g to 1.92 +/- 0.85 g for amitriptyline) in mice [1]. Oral rufinamide suppressed pentylenetetrazol-induced seizures in mice (ED(50) 45.8 mg/kg) but not rats, and was active against MES-induced tonic seizures in mice (ED(50) 23.9 mg/kg) and rats (ED(50) 6.1 mg/kg) [2]. Intraperitoneal rufinamide suppressed pentylenetetrazol-, bicuculline-, and picrotoxin-induced clonus in mice (ED(50) 54.0, 50.5, and 76.3 mg/kg, respectively). Clinical trial: Exploratory Study to Evaluate the Effect of SYN-111 (Rufinamide) in Patients With Generalized Anxiety Disorder (GAD). Phase 2

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 100mg
Available: In stock
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