ML224

Item no.	CS-3824-50mg
Manufacturer	ChemScene
Amount	50mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Similar products	1338824-21-7
Available
Alternative Names	NCGC00242364; ANTAG3
CAS	1338824-21-7
Purity	>98%
Formula	C31H31N3O5
MWt	525.59
Solubility	DMSO : 100 mg/mL (190.26 mM; Need ultrasonic); H2O : < 0.1 mg/mL (insoluble)
Clinical Information	No Development Reported
Pathway	GPCR/G Protein
Target	TSH Receptor
Biological Activity	ML224(NCGC00242364; ANTAG3) is a selective TSHR inverse agonist; inhibits TSH-stimulated cAMP production with an IC50 = 2.3 uM. IC50 value: 2.3 uM [1] Target: TSHR agonist in vitro: ANTAG3 was selective for TSHR inhibition; half-maximal inhibitory doses were 2.1 uM for TSHR and greater than 30 uM for LH and FSH receptors [2]. in vivo: In mice treated with TRH, ANTAG3 lowered serum free T4 by 44% and lowered mRNAs for sodium-iodide cotransporter and thyroperoxidase by 75% and 83%, respectively. In mice given M22, ANTAG3 lowered serum free T4 by 38% and lowered mRNAs for sodium-iodide cotransporter and thyroperoxidase by 73% and 40%, respectively [2].

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