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TRIM11 Antibody

TRIM11 Antibody

Item no.	OACA05892
Manufacturer	AVIVA Systems Biology
Amount	50 ug
Category	Neuroscience Neural Lineage Markers Neural Transcription Factors Molecular Targets for Neuroscience Neural Development Antibodies Immunohistochemistry ELISA Primary Antibodies Immunostaining
Type	Antibody Polyclonal
Format	Liquid
Applications	IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
Citations	[1]"TRIM E3 ligases interfere with early and late stages of the retroviral life cycle." Uchil P.D., Quinlan B.D., Chan W.T., Luna J.M., Mothes W. PLoS Pathog. 4:E16-E16(2008). [2]"TRIM11 binds to and destabilizes a key component of the activator-mediated cofactor complex (ARC105) through the ubiquitin-proteasome system." Ishikawa H., Tachikawa H., Miura Y., Takahashi N. FEBS Lett. 580:4784-4792(2006). [3]"The tripartite motif family identifies cell compartments." Reymond A., Meroni G., Fantozzi A., Merla G., Cairo S., Luzi L., Riganelli D., Zanaria E., Messali S., Cainarca S., Guffanti A., Minucci S., Pelicci P.G., Ballabio A. EMBO J. 20:2140-2151(2001).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	BIA1;E3 ubiquitin-protein ligase TRIM11;Protein BIA1;RING finger protein 92;RING-type E3 ubiquitin transferase TRIM11;RNF92;tripartite motif-containing protein 11.
Shipping Condition	Cool pack
Available
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	TRIM11
Gene Fullname	tripartite motif containing 11
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway. Mediates MED15 ubiquitination leading to proteasomal degradation. May contribute to the innate restriction of retroviruses. Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression. Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain. May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle.
Nucleotide accession_num	NM_145214
Protein accession_num	NP_660215
Protein name	E3 ubiquitin-protein ligase TRIM11
Clonality	Polyclonal
Purification	Protein G Purified
Immunogen	Recombinant Human E3 ubiquitin-protein ligase TRIM11 protein (267-468AA)
Formulation	50% Glycerol, 0.01M PBS, PH 7.4

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50 ug

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