Mouse Anti-Human Fas Ligand Clone ALF1.2 mAb

Fas ligand (FasL), also known as CD95L, is a member of the TNF family and induces apoptosis via binding to Fas (CD95). The protein exists in two forms, either membrane FasL or soluble FasL, which migrate at molecular weight of 45 kDa and 26 kDa, respectively. FasL is expressed on a variety of cells including activated lymphocytes, natural killer cells and monocytes. Interaction of FasL and Fas plays an important role in physiological apoptotic processes. Malfunction of the Fas-FasL system causes hyperplasia in peripheral lymphoid organs and accelerates autoimmune disease progression and tumorigenesis. ALF1.2 antibody reacts with FasL-transfected cells and recognizes soluble and membrane bound forms of human FasL. Isotype: Mouse IgG2a, Formulation: Purified immunoglobulin in phosphate buffered saline, pH 7.2, with 1% bovine serum albumin. Preservative: 0.1% sodium azide. Purification: Purified from ascites by Protein A/G chromatography. Immunogen: Recombinant soluble, active form of human Fas ligand. Cross-reactivity: Human.