Mouse Anti-Human TLR8 Clone 44B05 mAb

Mouse Anti-Human TLR8 Clone 44B05 monoclonal antibody. The Toll-like receptor (TLR) family of proteins are characterized by a highly conserved Toll homology (TH) domain, which is essential for Toll-induced signal transduction. TLR1 contains an extracellular domain consisting of several leucine-rich regions along with a single cytoplasmic Toll/IL-1R-like domain. TLR2 and TLR4 are activated in response to lipopolysacchride (LPS) stimulation, which results in the activation and translocation of NFeB and suggests that these receptors are involved in mediating inflammatory responses. TLR6 is highly homologous to TLR1, and like other members of the TLR family, it induces NFeB signaling upon activation. TLR8 gene contains three exons, two of, which have coding function. Expression of TLR receptors is highest in peripheral blood leukocytes, macrophages, and monocytes.

Recombinant human TLR8

Store at -20C. For long term storage, aliquot and store at -80C. Avoid repeated freeze-thaw cycles.