Rabbit Anti-Human CDKN1B/p27KIP1 Clone Poly6029 Affinity Purified pAb

p27Kip1 (cyclin-dependent kinase inhibitor 1B, cyclin-dependent kinase inhibitor p27) is a 27kD cyclin-dependent inhibitor. p27Kip1 is localized in the nucleus and cytoplasm (phospho-specific). This protein functions in G1 arrest and binds and inhibits complexes formed by cyclin E-CDK2, cyclin A-CDK2. p27Kip1 mediates TGF a-induced G1 arrest and regulates cell motility. This kinase has also been implicated in translational control. Akt phosphorylation causes p27 Kip1 export to cytoplasm, p27 Kip1 has also been shown to be ubiquitinated. p27 Kip1 has been shown to interact with NUP50, Skp2, and PKB/Akt. The Poly6029 antibody recognizes the C-terminal region of human p27Kip1 and has been shown to be useful for Western blot.

Peptide derived from the carboxy terminus of human p27

0.5 mg/ml