Rabbit Anti-Mouse CASP8 Active Affinity Purified pAb

Store at -20C or in working aliquots at -80C for long term storage. Avoid repeated freeze-thaw cycles.

Rabbit Anti-Mouse Active Caspase 8 Affinity Purified polyclonal antibody. Caspase 8, a member of the caspase family, of proteases, plays a key role in mediating Fas (CD95) and TNF induced apoptosis. Caspase 8 is synthesized as inactive pro-enzyme and activation of the enzyme involves proteolytic cleavage that leads to the release of the active p18 and p10 subunits. Activated caspase 8 is able to cleave and activate downstream caspases, such as caspase 3, -6, -7 and a death agonist member of the BCL2/BCL-xL family, Bid, leading to apoptosis.

Synthetic peptide corresponding to residues surrounding amino acid 392 of mouse Caspase 8

Detects the 25 kDa large subunit of Caspase 8. Does not detect the full length Caspase 8.