Rabbit Anti-Mouse Fas/Apo1 Affinity Purified pAb

Store at -20C or in working aliquots at -80C for long term storage. Avoid repeated freeze-thaw cycles.

Rabbit Anti-Mouse FAS Affinity Purified polyclonal antibody. Fas/Apo1 is a cell surface type-I membrane glycoprotein with an apparent molecular weight of 44 kDa on SDS-PAGE. Fas is a member of the TNFR family that includes TNFR1, TNFR2, CD27, CD30, and CD40. Binding of Fas-ligand (FasL) to Fas or crosslinking of Fas by anti-Fas monoclonal antibodies leads to apoptosis in Fas expressing cells. Both Fas and TNF-R contain the 70 amino acids cytoplasmic “death domain” that is, responsible for transmitting signal for apoptosis.

Synthetic peptide corresponding to residues surrounding amino acid 32 of mouse Fas.

Detects a 55 kDa form of glycosylated Fas, a 35 kDa native form of Fas, and a 29 kDa form of cleaved Fas fragment on SDS-PAGE immunoblots.