Mouse Anti-Rat IL-10 Clone 2G101H7 mAb

Mouse Anti-Rat IL-10 Clone 2G101H7 monoclonal antibody. IL-10 is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. It has pleiotropic effects in immunoregulation and inflammation. IL-10 down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. It can block NF-kappa B activity and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggest that IL-10 is an essential immunoregulator in the intestinal tract.

Recombinant rat IL-10

Store at -20C. Centrifuge vial prior to opening. Upon initial thawing, aliquot into small volumes and store at -20C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.