Rabbit Anti-Rat MIF pAb

Antibodies

For Western blot, use a working dilution of 1:2000. For Immunohistochemistry, use a working dilution of 1:500. The optimal concentration should be determined by the user for each specific application.

Macrophage Migration Inhibitory Factor (MIF) was one of the first cytokine activities to be discovered and was initially described as a T-cell derived factor that inhibits the random migration of macrophages. Recently, MIF was rediscovered as a pituitary hormone that acts as the counter-regulatory hormone for glucocorticoid action within the immune system. MIF was released from macrophages and T-cells in response to physiological concentrations of glucocorticoids. The secreted MIF counter-regulates the immunosuppressive effects of steroids on immune cell activation and cytokine production. MIF plays a critical role in the host control of inflammation and immunity.

Recombinant full-length rat MIF

Centrifuge vial prior to opening. Reconstitute to 1 mg/ml with 200 ul sterile distilled water.