Recombinant Human BMP-14

GDF5 is a bone morphogenetic protein (BMP). BMPs belong to the TGF-a superfamily of structurally related signaling proteins. As implied by their name, BMPs promote and regulate bone development, growth, remodeling and repair, in both prenatal development and postnatal growth of eye, heart, kidney, skin, and other tissues. In addition to its osteogenic activity, GDF5 is a principal inhibitor of cartilage development and is predominantly expressed in long bone during human embryonic development. Recombinant human GDF5 is a homodimeric protein consisting of two 120 amino acid polypeptide chains.

Lyophilized from 10 mM sodium citrate, pH 3.5

Centrifuge vial prior to opening. First add sterile distilled water containing BSA (50 ug BSA per 1 ug of protein) to the vial to fully solubilize the protein to a concentration of 0.1-1.0 mg/ml. After complete solubilization of the protein, it can be further diluted to other aqueous solutions. Please note that the addition of any carrier protein into this product may produce unwanted endotoxin. This depends upon the particular application employed.