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Recombinant Human 4-1BB Receptor

Recombinant Human 4-1BB Receptor

Manufacturer	Cell Sciences
Category	Oncology Neuroscience Neuroinflammation Metabolism Diabetes Peptides & Proteins Recombinant Proteins Cell Biology Obesity Cell Culture Cytokines Cell Status Necrosis Apoptosis
Type	Proteins
Specific against	Human
Amount	20 ug
Host	E.coli
Item no.	CS-CRB201B
Targets	TNF
eClass 6.1	34160400
eClass 9.0	42020190
Available
Biological Activity	Fully biologically active when compared to standard. The biological activity is measured by its binding ability in a functional ELISA. When Recombinant Human 4-1BB Receptor is immobilized at 10 ng/ml, the concentration of Recombinant Human 4-1BB Ligand that produces 50% optimal binding response is found to be approximately 0.5-2.5 ng/ml.
Description	Human 4-1BB Receptor, also named TNFRSF9, is a single non-glycosylated polypeptide chain containing 166 amino acids. 4-1BB Receptor is a member of the TNF superfamily of receptors. It is mainly expressed on the surface of a variety of T cells, but also found in B cells, monocytes, and various transformed cell lines. 4-1BB Receptor binds to 4-1BBL to provide a co-stimulatory signal for T lymphocytes. Signaling by 4-1BB Receptor has been implicated in the antigen-presentation process and generation of cytotoxic T cells.
Endotoxin Level	< 1 EU/ug as determined by LAL method.
Formulation	0.2 um sterile filtered and lyophilized in 10 mM PB, pH 8.0, + 150 mM NaCl.
Molecular Weight	17.7 kDa
Reconstitution	Centrifuge vial prior to opening. First add sterile distilled water to the vial to fully solubilize the protein to a concentration not less than 100 ug/ml. After complete solubilization of the protein, it can be further diluted to other aqueous solutions.
Storage and Stability	Store lyophilized protein at -20C to -80C. Reconstituted protein is stable for 1 week at 2-4C. For long term storage, aliquot and store at -20C to -80C with a carrier protein (0.1% HSA or BSA) as a stabilizer. This depends upon the particular application employed. Avoid repeated freeze-thaw cycles.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.