Recombinant Human SDF-1 beta

Stromal-Cell Derived Factor-1 beta (SDF-1beta), also known as SCYB12, PBSF and CXCL12, is an 8.3 kDa, heparin-binding member of the CXC (or alpha) family of chemokines and signal through the CXCR4 receptor. SDF-1alpha and beta are reported to be monomers at neutral pH and physiologic ionic strength. On the cell surface, this may well facilitate SDF-1 interaction with its two receptors, CXCR4 and syndecan4. Heparin sulfate is known to protect SDF-1 from proteolysis, and CXCR4 exists constitutively as a dimer. Among its many functions, CXCL12 is known to influence lymphopoiesis, regulate patterning and cell number of neural progenitors, and promote angiogenesis (12, 13). It also enhances the survival of myeloid progenitor cells. Recombinant Human SDF-1 beta is a single non-glycosylated polypeptide chain containing 72 amino acid residues.

Lyophilized from a 0.2 um filtered concentrated solution in PBS, pH 7.4.

Centrifuge vial prior to opening. Add sterile distilled water or aqueous buffer to a concentration of 0.1-1.0 mg/ml. Further dilutions should be made in appropriate buffered solutions.

>3.3 x 10E4 IU/mg.