Comparison

Recombinant Human Ubiquitin K48R (Lys 48 to Arg 48 mutation)

Item no. CS-CRU105B
Manufacturer Cell Sciences
Amount 20 ug
Category
Type Proteins
Specific against Human (Homo sapiens)
Host E.coli
Purity > 95% as determined by SDS-PAGE.
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Similar products RPS27A, Ubiquitin, CEP80, UBA80, UBCEP1, UBCEP80, Ribosomal Protein S27a, HUBCEP80, Ubiquitin K48R.
Available
Manufacturer - Category
Biomolecules
Storage Conditions
Store vial at -20C to -80C. When stored at the recommended temperature, this protein is stable for 12 months. Avoid repeated freezing and thawing cycles.
Description
Ubiquitin is a highly conserved 76 amino acid protein expressed in all eukariotes. Ub is found either in free form or conjugated to proteins as monomer or as chain of ubiquitin molecules. The most well characterized consequence of polyubiquitination is substrate degradation, while mono-ubiquitinated proteins are not degraded. Ubiquitin attachment to protein substrate is a complex process involving a ubiquitin activating enzyme (E1), a ubiquitin conjugating enzyme (E2) and a ubiquitin protein ligase (E3). The first ubiquitin moiety is transferred to the e-NH2 group of a Lys residue of the protein substrate to generate an isopeptide bond. In successive reactions, a poly ubiquitin chain is synthesized by processive transfer of additional activated moieties to Lys48 of the previously conjugated ubiquitin molecule. Ubiquitin K48R prevents the formation of poly ubiquitin chains via Lys48 linkages with mono ubiquitin molecules, avoiding the degradation of protein substrates. Recombinant Human Ubiquitin featuring a Lys 48 to Arg48 mutation is useful for the reduction of poly-Ub chain length and conjugation rates. Ubiquitin K48R is purified by proprietary chromatographic techniques.
Formulation
Diluted in PBS+ 5% glycerol.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 20 ug
Available: In stock
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