Recombinant Human HTRA2 (aa 134-458) His

Store at 4C if entire vial will be used within 2-4 weeks. Store frozen at -20C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

HTRA2 is a mammalian serine protease at high temperatures and has a chaperone activity at low temperature. The full-length HTRA2 is synthesized as a precursor protein and then targeted to the mitochondria where it matures by the removal of 133 N-terminal residues. Mature HTRA2 consists of a putative transmembrane domain, an inhibitor of apoptosis protein-binding motif, and a single C-terminal PDZ domain that mediates protein-protein interactions. HTRA2 has been shown to contribute to caspase-dependent and caspase-independent cell death. Recombinant Human HTRA2 is a single, non-glycosylated polypeptide chain consisting of aa 134-458 fused to a His tag at the C-terminus. It is purified by proprietary chromatographic techniques.