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E3LZ10.7 cells

E3LZ10.7 cells

Item no.	C0018005
Manufacturer	Addexbio
Amount	One Frozen vial
Category	Oncology Neuroscience Targets for Rodent Neurosciences Cell Lines & Cell Culture Cell Lines By Organ Lung Cancer Colorectal Cancer Pancreatic Cancer
Type	Tumour Cells
Specific against	Human (Homo sapiens)
Dry ice	Yes
Citations	1.Bisht, S., Brossart, P., Maitra, A., and Feldmann, G. Agents targeting the Hedgehog pathway for pancreatic cancer treatment using E3LZ10.7 cells. Curr Opin Investig Drugs, 11: 1387-1398. 2.Feldmann, G., Fendrich, V., McGovern, K., Bedja, D., Bisht, S., Alvarez, H., Koorstra, J. B., Habbe, N., Karikari, C., Mullendore, M., Gabrielson, K. L., Sharma, R., Matsui, W., and Maitra, A. An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer using E3LZ10.7 cells. Mol Cancer Ther, 7: 2725-2735, 2008. 3.Feldmann, G., Habbe, N., Dhara, S., Bisht, S., Alvarez, H., Fendrich, V., Beaty, R., Mullendore, M., Karikari, C., Bardeesy, N., Ouellette, M. M., Yu, W., and Maitra, A. Hedgehog inhibition prolongs survival in a genetically engineered mouse model of pancreatic cancer using E3LZ10.7 cells. Gut, 57: 1420-1430, 2008. 4.Feldmann, G., Dhara, S., Fendrich, V., Bedja, D., Beaty, R., Mullendore, M., Karikari, C., Alvarez, H., Iacobuzio-Donahue, C., Jimeno, A., Gabrielson, K. L., Matsui, W., and Maitra, A. Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases uisng E3LZ10.7 cells: a new paradigm for combination therapy in solid cancers. Cancer Res, 67: 2187-2196, 2007. 5. Embuscado EE, Laheru D, Ricci F, Yun KJ, de Boom Witzel S, Seigel A, Flickinger K, Hidalgo M, Bova GS, Iacobuzio-Donahue CA. Immortalizing the complexity of cancer metastasis: genetic features of lethal metastatic pancreatic cancer obtained from rapid autopsy. Cancer Biol Ther. 4(5):548-54, 2005.
ECLASS 10.1	32160890
ECLASS 11.0	32160890
UNSPSC	41106509
Available
Description	Disease: Pancreatic adenocarcinoma Origin: Derived from metastatic liver tumor (clinical stage IV) Species: Homo sapiens Tissue: Pancreas Morphology: Epithelial Properties: Adherent Cytogenic data: Tumorigenic in xenograft model, KRAS mutation: G12D, p53 mutation: WT, SMAD4 mutation: homozygous deletion. Patient: Male, Caucasian, 60 yrs of age Medium: AddexBio-formulated DMEM (C0003-01) + 10% FBS + 1x Non-essential amino acid Subculture: 1:2 to 1:4 using 0.25% trypsin or trypsin/EDTA, 5% CO2; 37C Freezing Medium: Complete culture medium supplemented with 5% (v/v) DMSO Biosafety Level: I Sterility: Bacteria: Negative Yeast: Negative Mycoplasma: Negative Pathogens: HIV: Negative Hepatitis B: Negative Hepatitis C: Negative Related cells by Organ: AR-42J cells BxPc-3 cells Capan-1 cells MIA PaCa-2 cells E3LZ10.7 cells A10.7 cells INS-1 cells MIN-6 cells
Storage condition	LN2
Manufacturers Category	Cell Lines

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: One Frozen vial

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