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AZD7762

AZD7762

Manufacturer	ChemieTek
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Amount	50mg
Item no.	CT-A7762-50
eClass 6.1	30220300
eClass 9.0	32160605
Available
CASRN	860352-01-8
Brief Description	AZD7762 is a potent ATP-competitive checkpoint kinase inhibitor with IC50s at 5 nM and <10 nM for CHK1 and CHK2, respectively, currently in clinical trials.
Solubility	Soluble in DMSO, Water
Storage	Store at 0° C (short term), -20° C (long term), desiccated
Purity	>99.5% chem and optical purity (HPLC and chiral HPLC at 214 and 254 nm)
Original QC Data	HPLC-MS, ¹HNMR, Chiral HPLC and Quantitative Elemental Analysis
Shipping Conditions	Ambient Temp.
References	1. S. Ashwell , et al., DNA Damage Detection and Repair Pathways Recent Advances with Inhibitors of Checkpoint Kinases in Cancer Therapy. Clin. Cancer Res. 2008, 14(13), 4033-4037. 2. SD Zabludoff, et al., AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies. Mol. Cancer Ther. 2008, 7(9), 2955-2966. 3. L Carrassa, et al., Role of Chk1 in the differentiation program of hematopoietic stem cells. Cell. Mol. Life Sci. 2010, 67, 1713-1722.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50mg

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Delivery expected until 6/6/2024