AVN944

Item no.	CT-AVN944-5
Manufacturer	ChemieTek
CASRN	297730-17-7
Amount	5 mg
Quantity options	10 mg 100 mg 200 mg 5 mg 50 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	>99.5% chem and stereomerical purity (HPLC and Chiral HPLC at 214 and 254 nm)
Citations	1. D. Floryk, et al., Antiproliferative effects of AVN944, a novel inosine 5-monophosphate dehydrogenase inhibitor, in prostate cancer cells, International Journal of Cancer (2008), 123(10), 2294-2302. 2. J. Hamilton, et al., A phase I dose-ranging study of the pharmacokinetics, pharmacodynamics, safety, and tolerability of AVN944, an IMPDH inhibitor, in healthy male volunteers, Journal of Clinical Pharmacology (2009), 49(1), 30-38. 3. M. Huang, et al., Depletion of guanine nucleotides leads to the Mdm2-dependent proteasomal degradation of nucleostemin, Cancer Research (2009), 69(7), 3004-3012.
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	VX-944, AVN-944
Available
Storage Conditions	Store at 0°C (short term), -20°C (long term), desiccated
Brief Description	AVN-944 (VX-944) is an orally available, uncompetitive small molecule inhibitor of inosine monophosphate dehydrogenase (IMPDH), an enzyme catalyzing the rate limiting step in the biosynthesis of guanine nucleotides. As IMPDH is overexpressed in some cancer cells, particularly in hematological malignancies, thus inhibition of this enzyme will result in depletion of guanine nucleotide pools, cessation of DNA synthesis, cell cycle block at the Gr(1)/S interface and interference with cell division, and induction of apoptosis. The reduction in guanine nucleotide pools will also interfere with the ability of G-coupled proteins to act as intracellular signal transducers.
Original QC Data	HPLC-MS, ¹HNMR, Chiral HPLC and Quantitative Elemental Analysis
Solubility	Soluble in DMSO

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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