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CAL-101

CAL-101

Item no.	CT-CAL101-50
Manufacturer	ChemieTek
CASRN	1146702-54-6
Amount	50 mg
Quantity options	10 mg 100 mg 200 mg 50 mg 500 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	>99% and 98% chem purity (HPLC at 254 nm and 214 nm); 99% optical purity (chiral HPLC)
Citations	1. Lannutti BJ, Meadows SA, Herman SE, Kashishian A, Steiner B, Johnson AJ, Byrd JC, Tyner JW, Loriaux MM, Deininger M, Druker BJ, Puri KD, Ulrich RG, Giese NA. CAL-101, a p110{delta} selective phosphatidylinositol-3-kinase inhibitor (PI3K) for the treatment of B cell malignancies inhibits PI3K signaling and cellular viability. Blood. 2010 Oct 19. [Epub ahead of print]. 2. Kahl BS, Cheson BD, Friedberg JW. Clinical Roundtable Monograph: current treatment options for NHL patients refractory to standard therapy: recent data in single-agent and combination therapy. Clin Adv Hematol Oncol. 2010 May;8(5):1-16. 3. Herman SE, Gordon AL, Wagner AJ, Heerema NA, Zhao W, Flynn JM, Jones J, Andritsos L, Puri KD, Lannutti BJ, Giese NA, Zhang X, Wei L, Byrd JC, Johnson AJ. Phosphatidylinositol 3-kinase-δ inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals. Blood. 2010 Sep 23;116(12):2078-88.
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Idelalisib, GS-101
Available
Storage Conditions	Store at 0°C (short term), -20°C (long term), desiccated
Brief Description	CAL-101 is a PI3K/P110δ isoform-specific inhibitor with IC₅₀ value of 2.5 nM, selective against other isoforms: p110α (820 nM), p110β (565 nM) and P110γ (89 nM).
Original QC Data	LC/MS, HPLC, ¹HNMR and Chiral HPLC
Solubility	Soluble in DMSO

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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