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CEP-28122

CEP-28122

Item no.	CT-CEP281-100
Manufacturer	ChemieTek
CASRN	1022958-60-6
Amount	100 mg
Quantity options	10 mg 100 mg 5 mg 50 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	100% optical purity (Chiral HPLC), 99.5% chemical purity (HPLC at 214 and 254 nm)
Citations	1. M. Cheng, et al., CEP-28122, a Highly Potent and Selective Orally Active Inhibitor of Anaplastic Lymphoma Kinase with Antitumor Activity in Experimental Models of Human Cancers. Mol Cancer Ther. 2012 Mar;11(3):670-9. 2. M. J. Jacobs, et al, Fused bicyclic 2,4-diaminopyrimidine derivative as a dual alk and fak inhibitor, WO2013134353 A1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Storage Conditions	Store at 0°C (short term), -20°C (long term), desiccated
Brief Description	CEP-28122 is a highly potent, selective and orally active ALK inhibitor (Ezymatic IC50: 1.9 nM (ref 1), 3 nM (ref 2), Cellular IC50: 30 nM (ref 2), Cellular IC50 in 75% murine: 300 nM (ref 2)), displaying a favorable pharmaceutical and pharmacokinetic profile and robust and selective pharmacologic efficacy against ALK-positive human cancer cells and tumor xenograft models in mice.
Original QC Data	HPLC-MS, ¹HNMR, Chiral HPLC, and Quantitative Elemental Analysis
Solubility	Soluble in DMSO

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 mg

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Delivery expected until 10/2/2025

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