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CEP-37440

CEP-37440

Item no.	CT-CEP374-5
Manufacturer	ChemieTek
CASRN	1391712-60-9
Amount	5 mg
Quantity options	10 mg 100 mg 200 mg 5 mg 50 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	>99% (HPLC at 214 and 254 nm), >99% optical purity (Chiral HPLC)
Citations	1. M. J. Jacobs, et al, Fused bicyclic 2,4-diaminopyrimidine derivative as a dual alk and fak inhibitor, WO2013134353 A1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Storage Conditions	Store at 0°C (short term), -20°C (long term), desiccated
Brief Description	CEP-37440 is a highly potent, selective and orally active inhibitor of ALK (Ezymatic IC50: 3.5 nM , Cellular IC50: 40 nM , Cellular IC50 in 75% human plasma: 120 nM) and FAK (Ezymatic IC50: 2.3 nM , Cellular IC50: 88 nM ), displaying a favorable pharmaceutical and pharmacokinetic profile and robust and selective pharmacologic efficacy against ALK /FAK mediated human cancer cells and tumor xenograft models in mice. It is currently in clinical trials
Original QC Data	HPLC-MS, ¹HNMR, Chiral HPLC and Quantitative Elemental Analysis
Solubility	Soluble in DMSO, and water with 2.0 eq. of HCl

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 5 mg

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Delivery expected until 10/2/2025

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