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Decernotinib

Decernotinib

Item no.	CT-DECE-10
Manufacturer	ChemieTek
CASRN	944842-54-0
Amount	10 mg
Quantity options	10 mg 100 mg 200 mg 5 mg 50 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	100% optical purity (Chiral HPLC), >99% purity (HPLC at 214 and 254 nm)
Citations	1. S. Mahajan, et al, VX-509 is a potent and selective Janus kinase 3 (JAK3) inhibitor that attenuates inflammation in animal models of autoimmune disease. J .Pharmacol Exp Ther. 2015 May;353(2):405-14. doi: 10.1124/jpet.114.221176. Epub 2015 Mar
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	VX-509
Available
Storage Conditions	Store at 0-4°C (short term), -20°C (long term), desiccated
Brief Description	Decernotinib (VX-509; VRT-831509, Adelatinib) is an orally bioavailable Janus kinase 3 (JAK3) inhibitor, potently and selectively inhibiting the enzyme with an in vitro Ki of 2.5 nM, and IC50 of 50-170 nM in cellular assays dependent on JAK3 activity. Highly selective, displaying no activity (with limited or no measureable potency) towards other JAK and non-JAK enzymes. Showed in vivo activity in two animal models of aberrant immune function, and demonstrated dose-dependent reduction in ankle swelling and paw weight and improved paw histopathology scores in the rat collagen-induced arthritis model (ref.1)
Original QC Data	HPLC-MS, ¹HNMR, Chiral HPLC, and Quantitative Elemental Analysis
Solubility	Soluble in DMSO

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 10 mg

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Delivery expected until 10/2/2025

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