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FRAX486

FRAX486

Manufacturer	ChemieTek
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Amount	10mg
Item no.	CT-F486-10
eClass 6.1	30220300
eClass 9.0	32160605
Available
CASRN	1232030-35-1
Brief Description	FRAX486 is an orally bioavailable and Blood-Brain Barrier (BBB) penetrable small molecule PAK (p21-activated kinase) inhibitor with IC50 values of 14, 33, 39 and 500 nM for PAK1, PAK2, PAK3 and PAK4, respectively
Solubility	Soluble in DMSO
Storage	Store at 0° C (short term), -20° C (long term), desiccated
Purity	>99% (HPLC at 214 and 254 nm)
Original QC Data	HPLC-MS, ¹HNMR, and Microanalysis
Shipping Conditions	Ambient Temp.
References	1.B. M. Dolan, et al, Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by the small-molecule PAK inhibitor FRAX486, PNAS, 2013, No 14, Vol 110 pp5671-5676

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Amount: 10mg

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Delivery expected until 6/6/2024