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GDC-0980

GDC-0980

Item no.	CT-G0980-5
Manufacturer	ChemieTek
CASRN	1032754-93-0
Amount	5 mg
Quantity options	10 mg 100 mg 200 mg 5 mg 50 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	>99% Chem and Optical Purity (HPLC and Chiral HPLC)
Citations	1. A. J. Wangner, et al, Mol Cancer Ther, Dec. 2009, Vol 8, Issue 12, Suppl. 1 2. D. P. Sutherlin, et al., Discovery of a Potent, Selective, and Orally Available Class I Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Kinase Inhibitor (GDC-0980) for the Treatment of Cancer, J. Med. Chem., 2011, 54 (21), pp 7579-7587
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	RG7422
Available
Storage Conditions	Store at 0°C (short term), -20°C (long term), desiccated
Brief Description	GDC-0980 is a potent, selective dual inhibitor of class I PI3K and mTOR kinase with in vitro IC50 of 4.8 nM for p110α /p85α and apparent Ki of 17.3 nM for human mTOR. It is currently in clinical Trial.
Original QC Data	HPLC-MS, ¹HNMR, Chiral HPLC, and Quantitative Elemental Analysis
Solubility	Soluble in DMSO

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 5 mg

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Delivery expected until 10/2/2025

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