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MK-1775

MK-1775

Item no.	CT-MK1775-50
Manufacturer	ChemieTek
CASRN	955365-80-7
Amount	50 mg
Quantity options	10 mg 100 mg 200 mg 5 mg 50 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	>99% (HPLC)
Citations	1: Leijen S, el at., Curr Clin Pharmacol. 2010 Apr 21. [Epub ahead of print] PubMed PMID: 20406171. 2: Hirai H, et al., Cancer Biol Ther. 2010 Apr 4;9 (7). [Epub ahead of print] PubMed PMID: 20107315. 3: Hirai H, et al., Mol Cancer Ther. 2009 Nov; 8(11):2992-3000. 4: Mizuarai S, et al., Mol Cancer. 2009 Jun 8; 8:34. PubMed PMID: 19500427; PubMed Central PMCID: PMC2700070.
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	AZD1775, Adavosertib
Available
Storage Conditions	Store at 0°C (short term), -20°C (long term), desiccated
Brief Description	MK-1775 is an inhibitor of Wee1, a kinase that phosphorylates CDC2 to inactivate the CDC2/cyclin B complex (regulating the G2 checkpoint). Since most human cancers harbor p53-dependent G1 checkpoint abnormalities, they are dependent on the G2 checkpoint. G2 checkpoint abrogation may therefore sensitize p53 deficient tumor cells to anti-cancer agents.
Original QC Data	HPLC-MS, ¹HNMR, and Quantitative Elemental Analysis
Solubility	Soluble in DMSO

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50 mg

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