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SCH900776

SCH900776

Item no.	CT-SCH900-100
Manufacturer	ChemieTek
CASRN	891494-63-6
Amount	100 mg
Quantity options	10 mg 100 mg 200 mg 5 mg 50 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	>99% chem and optical purity (HPLC and chiral HPLC at 215 and 254 nm)
Citations	1. T. J. Guzi, et al., Targeting the replication checkpoint using SCH 900776, a potent and functionally selective CHK1 inhibitor identified via high content screening. Mol Cancer Ther. 2011 Apr;10(4):591-602. 2. M. Labroli, et al., Discovery of pyrazolo[1,5-a]pyrimidine-based CHK1 inhibitors: A template-based approach - part 2. Bioorgan. & Med. Chem.Lett. 2011, 21(1):471-474
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	MK-8776
Available
Storage Conditions	Store at 0°C (short term), -20°C (long term), desiccated
Brief Description	SCH900776 is a potent, selective and orally bioavailable inhibitor of CHK1(IC50 = 3 nM), highly selective against CHK2 (IC50 = 1500 nM) and CDK2 (IC50 = 160 nM).* It is currently in clinical trials.
Original QC Data	HPLC-MS, ¹HNMR, Chiral HPLC, and Quantitative Elemental Analysis
Solubility	Soluble in DMSO

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 mg

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Delivery expected until 9/4/2025

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