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Tubacin

Tubacin

Item no.	CT-TUCN-5
Manufacturer	ChemieTek
CASRN	537049-40-4
Amount	5 mg
Quantity options	1 mg 10 mg 5 mg 50 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.8% chem purity (HPLC), >99% optical purity (Chiral HPLC, [α]<sup>20</sup><sub>D</sub> = - 54.9 <sup>o</sup> (c 0.443, MeOH))
Citations	1. Barua, Sutapa; Rege, Kaushal. The influence of mediators of intracellular trafficking on transgene expression efficacy of polymer-plasmid DNA complexes. Biomaterials (2010), 31(22), 5894-5902. 2. Hong, Jian; Xu, Xin; Das, Debasis; Yang, Pengyu; Chen, Shu-Hui; Li, Ge. A new approach to tubacin. Letters in Organic Chemistry (2010), 7(1), 50-53. 3. Bradner, James E.; West, Nathan; Grachan, Melissa L.; Greenberg, Edward F.; Haggarty, Stephen J.; Warnow, Tandy; Mazitschek, Ralph. Chemical phylogenetics of histone deacetylases. Nature Chemical Biology (2010), 6(3), 238-243.
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Storage Conditions	Store at 0°C (short term), -20°C (long term), desiccated
Brief Description	Tubacin is a specific inhibitor of HDAC6, one of 11 known human HDACs. Besides deacetylating tubulin, HDAC6 binds both polyubiquinated proteins (i.e., proteins marked for degradation by attached ubiquitin "flags") and dynein (a protein motor associated with microtubules), bringing the two together to help the cell clean house. This takes place through a recently described cell structure called the aggresome. There is growing evidence to support the relevance of HDAC6 and its non-histone substrates as a target for other cancers, including breast cancer. In addition, HDAC6 also targets another cellular protein known as Hsp90, a protein critical in helping other proteins achieve their correct conformation, including proteins implicated in many forms of cancer.
Original QC Data	HPLC, Chiral HPLC, MS and ¹HNMR
Solubility	Soluble in DMSO

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 5 mg

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