XL-147

Item no.	CT-XL147-200
Manufacturer	ChemieTek
CASRN	934526-89-3
Amount	200 mg
Quantity options	10 mg 100 mg 200 mg 50 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	>99% (HPLC at 214 and 254 nm)
Citations	1. GI Shapiro, et al., Phase I safety, pharmacokinetic, and pharmacodynamic study of SAR245408 (XL147), an oral pan-class I PI3K inhibitor, in patients with advanced solid tumors. Clin Cancer Res. 2014 Jan 1;20(1):233-45. doi: 10.1158/1078-0432.CCR-13-1777. 2. CP Reynolds, et al., Initial testing (stage 1) of the phosphatidylinositol 3' kinase inhibitor, SAR245408 (XL147) by the pediatric preclinical testing program. Pediatr Blood Cancer, 2013 May; 60(5):791-8. doi: 10.1002/pbc.24301. 3. L. Debussche, et al, Compositions comprising a pi3k inhibitor and a mek inhibitor and their use for treating cancer, EP 2648729 A1 (text from WO2012078832A1)
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Pilaralisib, SAR245408
Available
Storage Conditions	Store at 0°C (short term), -20°C (long term), desiccated
Brief Description	XL-147 (Pilaralisib) is a potent, selective and orally bioavailable ATP-competitive small molecule inhibitor targeting pan-class I phosphatidylinositol 3 kinase (PI3K) family with IC50 values of 39, 383, 36 and 23 nM for p110 α , β , δ and γ isoforms, and is highly selective over mTOR (IC50 > 15000 nM), VPS34 (IC50 = 6975 nM), DNAPK (IC50 = 4750 nM). It is currently in clinical trials for cancer treatment.
Original QC Data	HPLC-MS, ¹HNMR, Microanalysis (Elemental Analysis)
Solubility	Soluble in DMSO

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 200 mg

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Delivery expected until 7/31/2025

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