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Recombinant Human Interleukin 8 (a. a. 72) Polypeptide

Recombinant Human Interleukin 8 (a. a. 72) Polypeptide

Item no.	DAG323
Manufacturer	Creative Diagnostics
Amount	25 ug
Category	Oncology Neuroscience Neuroinflammation Metabolism Diabetes Neural Signaling By Cell Type Carcinoma Peptides & Proteins Peptides By Organ Lung Cancer Heart & Blood Cancer
Type	Peptides
Format	Lyophilized
Specific against	other
Purity	>98% pure (HPLC, FPLC and reducing and non-reducing SDS-PAGE).Endotoxin level is less than 0.1ng/ug (IEU/ug). Purified by chromatographictechniques. Product is sterile filtered.
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	IL8,Interleukin 8, NAF, GCP1, LECT, LUCT, NAP1, CXCL8, GCP-1, LYNAP, MDNCF,MONAP, NAP-1, interleukin-8, emoctakin, T-cell chemotactic factor,neutrophil-activating peptide 1, chemokine (C-X-C motif) ligand 8,beta-thromboglobulin-like protein, granulocyte chemotactic protein 1, tumornecrosis factor-induced gene 1, beta endothelial cell-derived neutrophilactivating peptide, lung giant cell carcinoma-derived chemotactic protein,small inducible cytokine subfamily B, member 8, K60, K 60, TSG-1, b-ENAP, GCP1,IL-8(9-77), OTTHUMP00000199825, 3-10C, TSG 1, TSG1, T cell chemotactic factor,SCYB 8, Protein 3-10C, Protein 3 10C, NAP 1, Neutrophil-activating protein 1,Neutrophil activating protein 1, Neutrophil-activating factor, Neutrophilactivating peptide 1, Neutrophil activating factor, Monocyte-derivedneutrophil-activating peptide, Monocyte-derived neutrophil chemotactic factor,Monocyte derived neutrophil chemotactic factor, Monocyte derived neutrophilactivating protein, Monocyte derived neutrophil activating peptide, MDNCF-c, MDNCF-b,Lymphocyte-derived neutrophil-activating factor, Lymphocyte derivedneutrophil activating factor, (Ala-IL-8)77, AMCF 1, (Ser-IL-8)72, AMCF-1, Emoctakin
Available
Manufacturer - Applications	Specific activity of Human IL-8 determined inchemotaxis of donor PBL neutrophils with threshold concentrationcorresponding to 10-100ng/ml. Each laboratory should determine an optimumworking titer for use in its particular application. Other applications havenot been tested but use in such assays should not necessarily be excluded.
Storage Conditions	The lyophilizedproduct, though stable for 3 weeks at room temperature, is best stored at–20°C. After reconstitution, short term (up to 1 week) store at 2-8oC. Longterm, add 0.1% HSA or BSA, aliquot and store at –20°C. Avoid multiplefreeze/thaw cycles.
Full name	Interleukin 8
Product Overview	RecombinantHuman IL-8 is a single, non-glycosylated polypeptide chain containing 72amino acids and having a molecular weight of 8, 452 Da. The sequence of thefirst five N-terminal amino acids was determined to be Ser-Ala-Lys-Glu-Leu.Contains less than 1% dimers and aggregates.
Abbr	IL8 (a.a. 72)
Manufacturer - Format	Purified, Lyophilized, Reconstitute using sterile deionizedwater to a concentration >100ug/ml. Further dilutions can be made in other aqueousbuffers.
Buffer	Not applicable
Concentration	Lot specific (OD280nm, E0.1% = 0.85) (prior tolyophilization)
Preservative	None
Gene Information - Gene Name	IL8interleukin 8 [ Homo sapiens ]
Gene Information - mRNA Refseq	NM_000584
Gene Information - Protein Refseq	NP_000575
Gene Information - MIM	146930
Gene Information - Pathway	ATF-2 transcriptionfactor network, Chagas disease (American trypanosomiasis), Calcineurin-regulated NFAT-dependent transcription in lymphocytes, Chemokinereceptors bind chemokines, Chemokine signaling pathway, Cytokine-cytokinereceptor interaction, Epithelial cell signaling in Helicobacter pyloriinfection, GPCR downstream signaling
Gene Information - Function	interleukin-8receptor binding, chemokine activity, protein binding
Antigen Description	IL-8is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It isreleased from several cell types in response to an inflammatory stimulus.IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) hasa higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 25 ug

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Delivery expected until 10/9/2025

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