MSR1 Antibody

MSR1

CD204 antibody; CD204 antigen antibody; CD24 antibody; Macrophage acetylated LDL receptor I and II antibody; Macrophage scavenger receptor 1 antibody; Macrophage scavenger receptor type III antibody; Macrophage scavenger receptor types I and II antibody; Msr 1 antibody; MSR1 antibody; MSRE_HUMAN antibody; phSR1 antibody; phSR2 antibody; SCARA 1 antibody; SCARA1 antibody; Scavenger receptor class A member 1 antibody; Scavenger receptor class A, member 1 antibody; Scavenger receptor type A antibody; Scvr antibody; SR A antibody; SRA antibody

Recombinant protein of human MSR1

This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimers disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages.

Affinity purification

Immunology

Recombinant protein of Human MSR1