PKZ18

Item no.	DCC-DC42762-10mg
Manufacturer	DCChemicals
CASRN	849658-87-3
Amount	10 mg
Quantity options	100 mg 10 mg
Category	In Vivo Reagents & Chemicals Molecules
Type	Chemicals
Applications	IV
Specific against	other
Smiles	[C@]12([H])C[C@]([H])(CC1)[C@@H](C(NC1=NC(C3=CC=C(C(C)C)C=C3)=C(C)S1)=O)[C@H]2C(O)=O
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Available
Manufacturer - Applications	PKZ18 is a novel antibiotic that effectively suppresses bacterial growth, exhibiting MIC values ranging from 32 to 64 μg/mL against a broad spectrum of Gram-positive bacteria. Its mechanism involves the selective inhibition of glycyl-tRNA synthetase mRNA transcription and translation in vivo. PKZ18 specifically targets stem I specifier loops in Gram-positive bacteria, disrupting T-box-mediated transcriptional read-through of downstream genes. By interfering with codon-anticodon recognition, it blocks essential tRNA binding and demonstrates a high barrier to resistance development.
Molecular Weight	398, 518444538116

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 10 mg

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Delivery expected until 12/11/2025

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