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ManidipineHcl

ManidipineHcl

Item no.	DCC-DC60037-250mg
Manufacturer	DCChemicals
CASRN	89226-75-5
Amount	250 mg
Quantity options	100 mg 1 g 250 mg
Category	Blocking Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Applications	Blocking, other
Specific against	other
Smiles	Cl[H].Cl[H].O(C(C1=C(C([H])([H])[H])N([H])C(C([H])([H])[H])=C(C(=O)OC([H])([H])[H])C1([H])C1C([H])=C([H])C([H])=C(C=1[H])[N+](=O)[O-])=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])(C2C([H])=C([H])C([H])=C([H])C=2[H])C2C([H])=C([H])C([H])=C([H])C=2[H])C([H])([H])C1([H])[H]
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Manufacturer - Applications	Manidipine 2Hcl (CV-4093) is a dihydropyridine compound and a calcium channel blocker for Ca2+ current with IC50 of 2.6 nM. IC50 value: 2.6 nMTarget: calcium channelManidipine is described to block T-type Ca2+ channels specifically and is also described to have a high selectivity for the vasculature, presenting negligible cardiodepression as compared to other Ca2+ channel antagonists. Manidipine is also described to not significantly affect norepinephrine levels, suggesting a lack of sympathetic activation with this compound. Manidipine reduces pro-inflammatory cytokines secretion in human endothelial cells and macrophages. Manidipine, unlike other third-generation dihydropyridine derived drugs, blocks T-type calcium channels present in the efferent glomerular arterioles, reducing intraglomerular pressure and microalbuminuria.
Molecular Weight	683, 627

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Amount: 250 mg

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Delivery expected until 9/25/2025

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