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Senexin C

Senexin C

Item no.	DCC-DC70766-100mg
Manufacturer	DCChemicals
CASRN	2375554-02-0
Amount	100 mg
Quantity options	100 mg 1 g 250 mg
Category	In Vivo
Applications	other, IV
Specific against	other
Smiles	N(C1=CC=NC2C=CC(C#N)=CC1=2)CCC1C=CC2C=C(C(N3CCN(C)CC3)=O)C=CC=2C=1
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Manufacturer - Applications	Senexin C is a novel potent, selective and orally bioavailable CDK8/19 inhibitor with Kd of 1.4 and 2.9 nM for CDK8/CycC and CDK19/CycC, respectively.Senexin C inhibits CDK8/CycC with IC50 of 3.6 nM, shows high selectivity against other HDAC isoforms.Senexin C is more metabolically stable and provides a more sustained inhibition of CDK8/19-dependent cellular gene expression when compared with the prototype inhibitor Senexin B.Senexin C inhibits MV4-11 leukemia growth in a systemic in vivo model with good tolerability.
Molecular Weight	449, 546885728836

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 mg

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Delivery expected until 12/11/2025

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