AIM2 Polyclonal Antibody

AIM2

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Interferon-inducible protein AIM2 (Absent in melanoma 2) is a 343 amino acid protein belonging to the HIN-200 family. Induced by IFN-, AIM2 is thought to act as a tumor suppressor by repressing NFB transcriptional activity. Localized to the nucleus, AIM2 contains one DAPIN domain and one HIN-200 domain. The DAPIN domain is composed mostly of -helixes and is a protein-protein interaction domain capable of binding other DAPIN domains. The HIN-200 domain has been shown to bind directly to DNA, which, along with the binding of another protein ASC, results in the activation of Caspase-1.

PBS with 0.05% sodium azide and 50% glycerol, PH7.4

IHC 1:50-1:200

AIM2

Recombinant protein of human AIM2