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HMGCS1 Polyclonal Antibody

HMGCS1 Polyclonal Antibody

Item no.	E-AB-16482-200
Manufacturer	Elabscience
Amount	200 uL
Quantity options	120 uL 20 uL 200 uL 60 uL
Category	Metabolism Diabetes Cholesterol & Lipid Metabolism Regulation of Appetite Antibodies Immunohistochemistry ELISA Enzymes Prostaglandin Synthases Primary Antibodies
Type	Antibody Polyclonal
Applications	IHC
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	3 hydroxy 3 methylglutaryl Coenzyme A synthase 1 (soluble), 3-hydroxy-3-methylglutaryl coenzyme A synthase, cytoplasmic, EC 2.3.3.10, HMCS1, HMG CoA synthase, HMG-CoA synthase, HMGCS, HMGCS1, Hydroxymethylglutaryl CoA synthase, cytoplasmic, Hydroxymethylglutaryl-CoA synthase, MGC90332
Similar products	HMGCS1, cytoplasmic, HMGCS, MGC90332, HMG CoA synthase, Hydroxymethylglutaryl CoA synthase, Hydroxymethylglutaryl-CoA synthase, 3-hydroxy-3-methylglutaryl coenzyme A synthase, HMG-CoA synthase, 3 hydroxy 3 methylglutaryl Coenzyme A synthase 1 (soluble), EC 2.3.3.10, HMCS1
Shipping Condition	Cool pack
Hazard information	Comply with cargo safety certificate
Available
Manufacturer - Category	Primary Antibodies
Manufacturer - Targets	HMGCS1
Shipping Temperature	The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions	Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Manufacturer - Research Areas	Cancer, Cardiovascular, Metabolism, Signal transduction
Background	HMG-CoA Synthase exists as both a mitochondrial (mHMGCS) and cytoplasmic (cHMGCS) enzyme that condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. The HMG-CoA produced by cHMGCS is transformed into mevalonate by HMG-CoA reductase, which starts isoprenoid biosynthesis. End products of the isoprenoid pathway include cholesterol, ubiquinone, dolichol, isopentenyl adenosine and farnesyl groups. mHMGCS, together with HMG-CoA Lyase, is responsible for ketone body biosynthesis. mHMGCS is expressed in liver and kidney. Fasting, cAMP and fatty acids increase the level of transcription of mHMGCS, while feeding and insulin repress it. A regulatory element within the mHMGCS promoter confers transcriptional regulation by PPAR, RXR, COUP-TF and HNF-4.
Concentration	0.6 mg/mL
Buffer	PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Purification Method	Affinity purification
Recommended Dilution	IHC 1:50-1:200
Santa Cruz #	sc-32422, sc-32423, sc-33829
Abbreviation	HMGCS1
Clonality	Polyclonal
Immunogen	Synthetic peptide of human HMGCS1
Category ID III	Polyclonal Antibodies

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.