BRCA1 Polyclonal Antibody

Store at -20C. Avoid freeze / thaw cycles.

180kDa

This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene.

PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol pH 7.4.

WB 1:500-1:2000, ELISA 1:5000

Synthesized peptide derived from human BRCA1 around the non-phosphorylation site of S1457.