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CHEK2 Polyclonal Antibody

CHEK2 Polyclonal Antibody

Item no.	E-AB-30918-200
Manufacturer	Elabscience
Amount	200 uL
Quantity options	120 uL 20 uL 200 uL 60 uL
Category	Oncology Neuroscience Neural Lineage Markers Targets for Rodent Neurosciences Neural Development Antibodies By Cell Type Blastoma Carcinoma Hematology Lymphoma Myeloma Melanoma Sarcoma Immunohistochemistry Western Blot ELISA Primary Antibodies Stem Cell Markers Progenitor Markers
Type	Antibody Polyclonal
Applications	WB, ELISA, IHC-P
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus), Monkey (Cynomolgus, Simian)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	CDS 1, Cds1, Cds1 homolog, Checkpoint kinase 2, Checkpoint like protein CHK2, CHEK 2, Chek2, Chk 2, CHK2 checkpoint homolog (S. pombe), CHK2 checkpoint homolog, CHK2, hCds1, HuCds 1, LFS 2, LFS2, PP1425, RAD 53, RAD53, Rad53 homolog, Serine/threonine protein kinase Chk2, Serine/threonine-protein kinase Chk2
Similar products	Serine/threonine-protein kinase Chk2, Cds1, CHK2, RAD53, LFS2, PP1425, hCds1, CHK2 checkpoint homolog, Cds1 homolog, Checkpoint kinase 2, CDS 1, Checkpoint like protein CHK2, Chek2, Chk 2, HuCds 1, LFS 2, RAD 53, Rad53 homolog, CHEK 2, CHK2 checkpoint homolog (S. pombe), Serine/threonine protein kinase Chk2
Available
Storage Conditions	Store at -20C. Avoid freeze / thaw cycles.
Calculated Molecular Weight	61kDa
Observed Molecular Weight	60kDa
Research Areas	Cancer, Epigenetics and Nuclear Signaling
Background	Regulates cell cycle checkpoints and apoptosis in response to DNA damage, particularly to DNA double-strand breaks. Inhibits CDC25C phosphatase by phosphorylation on 'Ser-216', preventing the entry into mitosis. May also play a role in meiosis. Regulates the TP53 tumor suppressor through phosphorylation at 'Thr-18' and 'Ser-20'.
Concentration	1mg/mL
Buffer	PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol pH 7.4.
Purification Method	Affinity purification
Recommended Dilution	WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:5000
Immunogen	Synthesized peptide derived from human Chk2 around the non-phosphorylation site of T383.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 200 uL

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Delivery expected until 9/11/2025

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