E2F4 Polyclonal Antibody

E2F4

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two.

PBS with 0.05% sodium azide and 50% glycerol, PH7.4

IHC 1:50-1:200

E2F4

Synthetic peptide of human E2F4