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NUAK1 Polyclonal Antibody

NUAK1 Polyclonal Antibody

Item no.	E-AB-16173-60
Manufacturer	Elabscience
Amount	60 uL
Quantity options	120 uL 20 uL 200 uL 60 uL
Category	Oncology Neuroscience Neural Lineage Markers Metabolism Molecular Targets for Neuroscience Targets for Rodent Neurosciences Neural Development Antibodies By Cell Type Hematology Lymphoma Myeloma Cell Biology Obesity Cell Status Immunohistochemistry ELISA Autophagy Primary Antibodies By Organ Lung Cancer Bladder Cancer Breast Cancer Progenitor Markers
Type	Antibody Polyclonal
Applications	IHC
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	AMP activated protein kinase family member 5, AMPK related protein kinase 5, AMPK-related protein kinase 5, NUAK family SNF1 like kinase, NUAK family SNF1-like kinase 1, Nuak1, NUAK1, Omphalocele kinase 1, Probable serine/threonine protein kinase KIAA0537
Similar products	NUAK1, NUAK family SNF1-like kinase 1, AMPK-related protein kinase 5, Omphalocele kinase 1, Nuak1, AMPK related protein kinase 5, NUAK family SNF1 like kinase, AMP activated protein kinase family member 5, Probable serine/threonine protein kinase KIAA0537
Shipping Condition	Cool pack
Hazard information	Comply with cargo safety certificate
Available
Manufacturer - Category	Primary Antibodies
Manufacturer - Targets	NUAK1
Shipping Temperature	The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions	Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Research Areas	Cancer, Signal Transduction
Background	NUAK family SNF1-like kinase 1also known asAMPK-related protein kinase 5(ARK5) is anenzymethat in humans is encoded by theNUAK1gene. Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1.
Concentration	1.4 mg/mL
Buffer	PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Purification Method	Affinity purification
Recommended Dilution	IHC 1:100-1:300
Santa Cruz #	sc-49366, sc-130117
Abbreviation	NUAK1
Clonality	Polyclonal
Immunogen	Synthetic peptide of human NUAK1
Category ID III	Polyclonal Antibodies

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.