Comparison

CADM1 Polyclonal Antibody

Item no. E-AB-33159-20
Manufacturer Elabscience
Amount 20 uL
Quantity options 120 uL 20 uL 200 uL 60 uL
Category
Type Antibody Polyclonal
Applications WB, IF, ELISA
Specific against Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host Rabbit
Isotype IgG
Conjugate/Tag Unconjugated
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Alias BL2, Cadm1, CADM1, Cell adhesion molecule 1, DKFZp686F1789, IgSF4, IGSF4A, Immunoglobulin superfamily member 4, MGC149785, MGC51880, NECL-2, NECL2, Nectin like 2, Nectin-like protein 2, RA175, SgIGSF, Spermatogenic immunoglobulin superfamily, ST17, sTSLC 1, Synaptic cell adhesion molecule, SynCAM, SynCAM1, TSLC-1, TSLC1, Tumor suppressor in lung cancer 1
Similar products SynCAM, CADM1, TSLC1, BL2, DKFZp686F1789, IGSF4A, MGC149785, MGC51880, NECL2, RA175, ST17, Cadm1, Cell adhesion molecule 1, Immunoglobulin superfamily member 4, Nectin-like protein 2, Spermatogenic immunoglobulin superfamily, Synaptic cell adhesion molecule, Tumor suppressor in lung cancer 1, TSLC-1, SynCAM1, SgIGSF, IgSF4, NECL-2, Nectin like 2, sTSLC 1
Available
Storage Conditions
Store at -20C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
49kDa
Observed Molecular Weight
49kDa
Research Areas
Cancer, Neuroscience
Background
Homologous to the poliovirus receptor (PVR/CD155), the Nectin immunoglobulin superfamily comprises four known isoforms, Nectin 1, 2, 3 and 4 (also designated TSLC1). TSLC1 is encoded by a tumor-suppressor gene in human non-small-cell lung cancer mapping to chromosome 11q23.2. The TSLC1 protein is an N-linked membrane glycoprotein that co-localizes with the Actin filament-binding protein, afadin, at cadherin-based adherens junctions in MDCKII epithelial cells. TSLC1 also interacts with the tumor-suppressor gene product DAL-1 (for differentially expressed in adenocarcinoma of the lung protein 1) to target Actin rearragement and cellular motility. TSLC1 may also form homodimers that function in homophilic, intracellular adhesion. TSLC1 expression is reduced or absent in a number of characterized cancer cell lines including A549. In prostate and breast cancer, as well as in pancreatic ductal adenocarcinoma, the TSLC1 promoter is commonly silenced by hypermethylation. Unlike other Nectins, which are more widely expressed, TSLC1 is mainly expressed in the placenta.
Concentration
1mg/mL
Buffer
PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification Method
Affinity purification
Recommended Dilution
WB 1:500-1:2000, IF 1:100-1:300, ELISA 1:20000
Immunogen
Synthesized peptide derived from the C-terminal region of human TSLC1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 20 uL
Available: In stock
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