CRK Polyclonal Antibody

CRK

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.

PBS with 0.05% sodium azide and 50% glycerol, PH7.4

IHC 1:50-1:200

CRK

Recombinant protein of human CRK