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Catenin beta Monoclonal Antibody

Catenin beta Monoclonal Antibody

Item no.	E-AB-22111-120
Manufacturer	Elabscience
Amount	120 uL
Quantity options	120 uL 20 uL 200 uL 60 uL
Category	Oncology Neuroscience Neural Adhesion Molecules Antibodies By Cell Type Blastoma Carcinoma Hematology Leukemia Adenocarcinoma Immunohistochemistry Western Blot Immunofluorescence Primary Antibodies
Type	Antibody Monoclonal
Applications	WB, IF, IHC-P
Clone	2E4
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Mouse
Isotype	IgG
Conjugate/Tag	Unconjugated
Citations	https://www.frontiersin.org/articles/10.3389/fonc.2021.669560/full
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Beta catenin, Beta-catenin, Cadherin associated protein, Catenin (cadherin associated protein), beta 1, 88kDa, Catenin beta 1, Catenin beta-1, CATNB, CHBCAT, CTNB1, CTNNB, CTNNB1, DKFZp686D02253, FLJ25606, FLJ37923, OTTHUMP00000162082, OTTHUMP00000165222, OTTHUMP00000165223, OTTHUMP00000209288, OTTHUMP00000209289
Similar products	Catenin beta-1, CTNNB1, CTNNB, Beta-catenin, Beta catenin, beta 1, DKFZp686D02253, FLJ25606, FLJ37923, OTTHUMP00000209288, Cadherin associated protein, CHBCAT, 88kDa, Catenin beta 1, CATNB, OTTHUMP00000162082, OTTHUMP00000165222, OTTHUMP00000165223, Catenin (cadherin associated protein), CTNB1, OTTHUMP00000209289
Shipping Condition	Cool pack
Hazard information	Comply with cargo safety certificate
Available
Manufacturer - Category	Primary Antibodies
Manufacturer - Targets	Catenin-β
Shipping Temperature	The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions	Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Observed Molecular Weight	92kDa
Research Areas	Cancer, Cardiovascular, Neuroscience, Signal Transduction, Stem Cells
Background	Key dowstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes.Involved in the regulation of cell adhesion. The majority of beta-catenin is localized to the cell membrane and is part of E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.
Concentration	1 mg/mL
Buffer	PBS with 0.02% sodium azide and 50% glycerol pH 7.4.
Purification Method	Protein A purification
Recommended Dilution	WB 1:500-1:2000; IHC 1:100-1:300; IF 1:100-1:300
Abbreviation	Catenin-β
Clonality	Monoclonal
Immunogen	Recombinant Protein
Category ID III	Monoclonal Antibodies

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.